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Retinol Night Serum: Retinol, Reimagined


What if we told you that there was a single, powerful formula for youthful skin that checked off every single one of your skincare goals? Now there is.

Meet our new Squalane + Retinol Night SerumWe've innovated a groundbreaking new retinol serum specifically to minimize irritation, so you can get all the benefits of retinol without redness and flaking.

Read on to learn how we’ve reimagined retinol for your healthiest skin ever.Shop Squalane + Retinol Night Serum

Why Do You Need Retinol?

Vitamin A derivatives called “retinoids” - such as retinol and retinaldehyde - have long been dermatologists’ go-to ingredients for promoting healthier, more youthful skin. And with good reason. Retinoids work differently from other skincare ingredients by traveling deeper into the skin, epidermis, to change it on a cellular level. improving cell renewal and growth. These changes make the skin thicker and more elastic, visibly minimizing fine lines and wrinkles, firming skin, and reversing sun damage from the inside out.

How Do Retinoids Benefit The Skin?

Retinoids, such as retinol and retinaldehyde (aka “retinal”):

  • Increase cell renewal and growth
  • Minimize the appearance of fine lines and wrinkles
  • Improve uneven skin tone
  • Reverse visible sun damage
  • Increase skin firmness
  • Boost collagen
  • Improve the look of blemishes
  • Promote skin radiance


2 Models with glowing skin

Why Do Retinoids Sometimes Irritate The Skin?

Despite their efficacy, some people find that retinoids can temporarily cause redness, flaking, and irritation when they first start using them.Two common reasons are:
  • The skin is exposed to too much active ingredient all at once, causing skin cells to turn over too quickly and exposing immature skin cells.
  • The retinoids in the product are unstable and have broken down, reducing their efficacy and increasing the chances of irritation.

Fortunately, our scientists were able to develop a retinol night serum that solves both problems, minimizing irritation while delivering a powerfully effective formula.

How We Reimagined Retinol

There are three key differences between our Squalane+ Retinol Night Serum and the other retinol face serums:

  1. Two Kinds Of Retinoids. We use both retinol, the gold standard for promoting youthful-looking skin, and retinal, the most powerful - and gentle - nonprescription retinoid, for double the power without the irritation.
  2. Our Time Release Technology. We encapsulate our retinoids to ensure maximum stability and absorption. The Vitamin A derivitive remains active within the skin and is gradually released over 8 hours while you sleep for minimal irritation.
  3. Our Squalane-Superpowered Delivery System. Our cruelty-free, sugarcane-based squalane delivers up to 40 times more of active skincare ingredients. In this retinol face serum, squalane makes our encapsulated retinoids work harder while keeping your skin hydrated, further minimizing risk of flaking, redness or irritation.
Shop Squalane + Retinol Night SerumRetinol Vs. Retinal vendiagram

Retinol, Reimagined

Not only did we encapsulate our retinoids for gentler, more controlled delivery, we went a step further to make them more stable.Antioxidants rosemary and saffron work within our formula to stabilize our retinoids while supporting overall skin health. This not only ensures that the active ingredients in our serum stay effective, it also means they won’t break down and irritate your skin.

What’s The Difference Between Squalane + Retinol Night Serum And Prescription Retinol?

Your skin is only able to use retinoids that are – or can be converted to – retinoic acid. Most prescription retinoids contain a Vitamin A derivative called “tretinoin,” which is pure retinoic acid. Tretinoin is only available with a prescription.

Our resurfacing retinol serum contains two powerfully gentle retinoids:

  • Retinaldehyde. The most powerful – and the gentlest – retinoid available without a prescription, retinaldehyde needs only one conversion to retinoic acid on the skin.
  • Retinol. Retinol is a best-in-class ingredient with proven efficacy in smoothing fine lines and wrinkles while improving skin texture and tone. It goes through two conversions before becoming retinoic acid.


By using both, we deliver the best of both worlds: the most powerful retinol product you can get without a prescription, but with visibly less irritation.

Your 3-Step routine featuring New Retinol Night Serum

How To Incorporate Squalane + Retinol Night Serum Into Your Skincare Routine

Shop Squalane + Retinol Night Serum

Our Squalane + Retinol Night Serum Layering Guide

Step One: At night, cleanse with our Squalane + Amino Aloe Gentle Cleanser. Pat Dry.

Step Two: Using your ring finger, tap a small amount of Squalane + Marine Algae Eye Cream onto the ocular bone beneath your eye.

Step Three: Apply a pea-sized amount of Squalane + Retinol Night Serum.

Step Four: Moisturize with Squalane + Omega Barrier Repair Cream.

Optional: Cocktail a drop or two of Squalane + Vitamin C Rose Oil into your cream for additional moisture and glow.

The next morning: Repeat steps one, two, and four. Then protect your skin with our reef-safe Squalane + Zinc Sheer Mineral Sunscreen.retinol Night Serum with Ingredients


  • Is your retinol “clean”? Yes. Our Squalane + Retinol Night Serum is made with sustainably-sourced ingredients that are safe for people and the planet.
  • Who should use this retinol serum? Retinol is best for those concerned with signs of aging, including fine lines, wrinkles and uneven skin tone. It can be used as both a preventative and corrective treatment.



  • Is this retinol night treatment safe for melanated skin tones? Absolutely! 


  • Can I use this night serum in the morning? No. Retinoids cause immediate, rapid cell turnover. If you use our retinol night treatment during the day, you’re exposing those brand new baby cells to harmful UV rays and doing more harm than good.


  • Why do I need to use sunscreen if I’m only using retinol at night? Your skin has been hard at work all night, building collagen and revealing fresh new skin cells. These cells are especially vulnerable to the sun, and exposing them to UV rays can lead to sun damage. 


  • Can I use this along with a bakuchiol product? We developed two different products for two types of customer’s unique needs. Please choose the single product that suits yours best.


  • Should I use a plant-based bakuchiol or should I use retinol? Which one is more effective?  The answer depends on what’s important to you. If you are concerned with lines and wrinkles and other visible skin aging, but also have sensitive skin, are prone to sunburn and/or are pregnant/lactating, Squalane + Phyto Retinol Serum may be a better choice. If your main concern is lines, wrinkles and other signs of aging and you are looking for faster and stronger actives, then Squalane + Retinol Night Serum may be a good option for you.
  • How can I combine this retinol face serum with other Biossance serums? We recommend using Squalane + Retinol Night Serum in the evening. In the morning,  use either our Squalane + Vitamin C Dark Spot Serum or Squalane + Copper Peptide Rapid Plumping Serum depending on your skincare goals. Since our retinol is a powerful serum, we don’t recommend layering with other treatment products, but do encourage you to layer with other moisturizers and oils. Our Squalane + Omega Repair Cream and Squalane + Vitamin C Rose Oil are both beautiful compliments to a routine including retinol.




  • Does your product contain BHT? BHT (butylated hydroxytoluene), is a synthetic additive used as an antioxidant and stabilizer. It’s controversial due to potential health concerns at high doses. There are conflicting reports on its safety, so we choose to avoid it.


  • Is your product fragrance-free? Yes. Any odor you may notice comes from the base ingredients listed on the packaging, not added fragrance.


  • Where can I buy Squalane + Retinol Night Serum? Right here on ourproduct page.


 Shop Squalane + Retinol Night Serum
Christine Tusher
Christine Tusher Writer and expert
As a lifestyle writer and journalist, I love sharing my passion for ocean conservation and obsession with clean beauty. I’ve tried almost every trend and ingredient, and Biossance’s science-backed formulas are the only ones that consistently calm my reactive skin and make it smoother, clearer, and healthier. I’m so excited to be on this journey of skincare innovation with Biossance, and to share it with you!

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